167869-21-8：产品说明书

167869-21-8：产品说明书

                                                <a href="https://www.medchemexpress.com/PD98059.html">PD98059</a>产品描述：PD98059 is an <b>MEK</b> inhibitor with <b>IC₅₀</b> of 5 μM, also suppresses TCDD binding to the aryl hydrocarbon receptor (AHR) with <b>IC₅₀</b> of 4 μM.IC50 &amp; Target: IC50: 5 μM (MEK)^[1]<i><b>In Vitro:</b></i> Concentrations of PD98059 of ≤20 μM are not cytotoxic to cultured MCF10A, MCF10A-Neo, and MCF10A-NeoT cells. However, PD98059 is weakly cytostatic to all three lines at concentrations of ≥10 μM. Treatment of MCF10A-Neo and MCF10A-NeoT cultures with concentrations of PD98059 up to 20 μM for 2-22 hr does not alter the total ERK content. However, treatment with PD98059 does result in concentration-dependent reductions in the dually phosphorylated forms of ERK1 and ERK2. Within 2 hr of a 10-μM treatment, phosphorylated ERK contents are reduced ~74% and ~86% in MCF10A-Neo and MCF10A-NeoT cultures, respectively (IC₅₀=1 μM). Within 22 hr of treatment, phosphorylated ERK forms are almost completely eliminated in both cell lines^{[1]<br /><br /><span    style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">公司介绍：MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库，总部位于美国新泽西，分别在瑞典和上海设有欧洲区子公司和亚洲区总代理，营销网点遍及全球20多个国家地区。MCE经过多年努力已成为全球生物活性小分子领域的一流供应商， 产品涵盖癌症、神经科学、抗感染、表观遗传学等20个热门研究领域，PI3K、MAPK等近千个细分靶点，超过4000个活性小分子化合物现货，以及GPCR、API、离子通道等超过20种不同类型的化合物库，同时提供从毫克到千克的专业定制合成服务。</span><br    style="color: rgb(62,62,62);" /><span    style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">MCE 对每批产品都进行严格的LCMS和NMR检验，其产品已被全球近万名客户广泛使用并发表大量文章、专利；</span><br    style="color: rgb(62,62,62);" /><span    style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">MCE 定期增加各领域热门抑制剂、激动剂，不断扩增已有化合物库，以满足最新的科研需求；</span><br    style="color: rgb(62,62,62);" /><span    style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">数千种产品在上海有充足备货，24-48小时内送达客户；</span><br    style="color: rgb(62,62,62);" /><span    style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">大量产品提供免费试用装；</span><span    style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">已为全球多个知名企业、院校构建各种定制型化合物库。</span><br /><br />产品链接：<a    href="http://www.medchemexpress.cn/pd98059.html">www.medchemexpress.cn/pd98059.html</a><br /><br /><img    alt=""    src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg" style="width: 600.0px;height: 310.0px;" />}                                            </div>