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NSC 663284

发布日期：2017-10-26   浏览次数：0
核心提示：a href=https://www.medchemexpress.com/NSC_663284.htmlNSC 663284/a产品描述：NSC 663284 is a bCdc25/b dual specificity pho
<a href="https://www.medchemexpress.com/NSC_663284.html">NSC 663284</a>产品描述：NSC 663284 is a <b>Cdc25</b> dual specificity phosphatases inhibitor with an <b>IC<sub>50</sub></b> of 0.21 μM.

IC50 & Target: IC50: 0.21 μM (Cdc25)<sup>[1]</sup>

<i><b>In Vitro:</b></i> The Cdc25 dual specificity phosphatases have central roles in coordinating cellular signaling processes and cell proliferation. NSC 663284 exhibits mixed competitive kinetics against Cdc25A, Cdc25B2, and Cdc25C with K<sub>i</sub> values of 29, 95, and 89 nM, respectively. NSC 663284 blocks cellular Erk dephosphorylation caused by ectopic Cdc25A expression. NSC 663284 displays a strong preference for Cdc25B2 as compared with VHR or PTP1B, the relative IC<sub>50</sub> values for Cdc25B2 are 20- and 450-fold lower than for VHR or PTP1B, respectively. NSC 663284 blocks cell proliferation and the actions of cellular cdc25a. NSC 663284 has a mean IC<sub>50</sub> value in the NCI 60 Cell Human Tumor Panel of 1.5 (0.6 µM when cells are treated for 48 h). Most sensitive are human breast cancer MDA-MB-435 and<br><br>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/nsc-663284.html">www.medchemexpress.cn/nsc-663284.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

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