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SQ22536

发布日期：2017-10-26   浏览次数：0
核心提示：a href=https://www.medchemexpress.com/SQ22536.htmlSQ22536/a产品描述：SQ22536 is an effective badenylate cyclase/b (bAC/b
<a href="https://www.medchemexpress.com/SQ22536.html">SQ22536</a>产品描述：SQ22536 is an effective <b>adenylate cyclase</b> (<b>AC</b>) inhibitor.

IC50 & Target: adenylate cyclase (AC)<sup>[1]</sup>

<i><b>In Vitro:</b></i> SQ22536 (SQ22,536) effectively inhibits the effect of forskolin with respective IC<sub>50</sub> values of 5 μM.Preincubation with graded concentrations of SQ22536 reveals that both SQ22536 effectively inhibits PACAP-induced reporter gene activation with approximate IC<sub>50</sub> value of 5 μM. SQ22536 more potently inhibits forskolin-induced Elk activation (IC<sub>50</sub>=10 μM) than 8-Br-cAMP-induced Elk activation (IC<sub>50</sub>=170 μM). Most notably, there are substantial differences in the reported potencies of SQ22536 to inhibit the activities of recombinant AC5 and AC6, with respective IC<sub>50</sub> values of 2 μM and 360 μM. At a greater concentration (500 μM), SQ22536 significantly inhibits neurite elongation due to either forskolin or 8-Br-cAMP<sup>[1]</sup>.

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<span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">公司介绍：MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库，总部位于美国新泽西，分别在瑞典和上海设有欧洲区子公司和亚洲区总代理，营销网点遍及全球20多个国家地区。MCE经过多年努力已成为全球生物活性小分子领域的一流供应商， 产品涵盖癌症、神经科学、抗感染、表观遗传学等20个热门研究领域，PI3K、MAPK等近千个细分靶点，超过4000个活性小分子化合物现货，以及GPCR、API、离子通道等超过20种不同类型的化合物库，同时提供从毫克到千克的专业定制合成服务。</span>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/sq22536.html">www.medchemexpress.cn/sq22536.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

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