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CPI-455

发布日期：2017-10-26   浏览次数：0
核心提示：a href=https://www.medchemexpress.com/CPI-455.htmlCPI-455/a产品描述：CPI-455 is a specific bKDM5/b inhibitor.IC50Target:
<a href="https://www.medchemexpress.com/CPI-455.html">CPI-455</a>产品描述：CPI-455 is a specific <b>KDM5</b> inhibitor.

IC50 & Target: KDM5<sup>[1]</sup>

<i><b>In Vitro:</b></i> CPI-455 mediates KDM5 inhibition, elevates global levels of H3K4 trimethylation (H3K4me3) and decreases the number of DTPs in multiple cancer cell line models treated with standard chemotherapy or targeted agents<sup>[1]</sup>. CPI-455, with high measured affinity for the target KDM5 proteins. Within 24 hours, increases in H3K4me3, but not H3K4me2, are observed after exposure to either of the two active compounds, CPI-455 and CPI-766, in a dosedependent manner. IC<sub>50</sub> calculation for KDM5 Inhibitor CPI0455 in 3 luminal breast cancer cell lines MCF-7, T-47 and EFM-19 are 35.4, 26.19 and 16.13 μM, respectively<sup>[2]</sup>.

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<span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">公司介绍：MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库，总部位于美国新泽西，分别在瑞典和上海设有欧洲区子公司和亚洲区总代理，营销网点遍及全球20多个国家地区。MCE经过多年努力已成为全球生物活性小分子领域的一流供应商， 产品涵盖癌症、神经科学、抗感染、表观遗传学等20个热门研究领域，PI3K、MAPK等近千个细分靶点，超过4000个活性小分子化合物现货，以及GPCR、API、离子通道等超过20种不同类型的化合物库，同时提供从毫克到千克的专业定制合成服务。</span>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/cpi-455.html">www.medchemexpress.cn/cpi-455.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

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