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AS1517499

发布日期：2017-10-26   浏览次数：0
核心提示：a href=https://www.medchemexpress.com/AS1517499.htmlAS1517499/a产品描述：AS1517499 is a potent bSTAT6/b inhibitor with b
<a href="https://www.medchemexpress.com/AS1517499.html">AS1517499</a>产品描述：AS1517499 is a potent <b>STAT6</b> inhibitor with <b>IC<sub>50</sub></b> of 21 nM.

IC50 & Target: IC50: 21 nM (STAT6)<sup>[1]</sup>

<i><b>In Vitro:</b></i> AS1517499 shows potent STAT6 inhibition with an IC<sub>50</sub> value of 21 nM, and also inhibits IL-4-induced Th2 differentiation of mouse spleen T cells with an IC<sub>50</sub> value of 2.3 nM and without influencing T-helper cell 1 (Th1) differentiation induced by IL-12. AS1517499 selectively inhibits Th2 differentiation without affecting Th1 differentiation<sup>[1]</sup>. In cultured human BSM cells, IL-13 (100 ng/mL) causes a phosphorylation of STAT6 and an up-regulation of RhoA, a monomeric GTPase responsible for Ca<sup>2+</sup> sensitization of smooth muscle contraction: both events are inhibited by co-incubation with AS1517499 (100 nM)<sup>[2]</sup>.

<i><b>In Vivo:</b></i> In BALB/c mice that are actively sensitized and repeatedly challenged with ovalbumin antigen, an increased IL-13 level in bronchoalveolar lavage flui<br><br>
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<span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">公司介绍：MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库，总部位于美国新泽西，分别在瑞典和上海设有欧洲区子公司和亚洲区总代理，营销网点遍及全球20多个国家地区。MCE经过多年努力已成为全球生物活性小分子领域的一流供应商， 产品涵盖癌症、神经科学、抗感染、表观遗传学等20个热门研究领域，PI3K、MAPK等近千个细分靶点，超过4000个活性小分子化合物现货，以及GPCR、API、离子通道等超过20种不同类型的化合物库，同时提供从毫克到千克的专业定制合成服务。</span>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/as1517499.html">www.medchemexpress.cn/as1517499.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

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