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YM-58483研究进展

发布日期：2017-10-27   浏览次数：0
核心提示：a href=https://www.medchemexpress.com/YM-58483.htmlYM-58483/a产品描述：YM-58483 is the first selective and potent inhibi
<a href="https://www.medchemexpress.com/YM-58483.html">YM-58483</a>产品描述：YM-58483 is the first selective and potent inhibitor of <b>CRAC channels</b> and subsequent Ca<sup>2+</sup> signals.

<i><b>In Vitro:</b></i> YM-58483 can decrease the levels of P-ERK and P-CREB, without affecting the expression of CD11b and GFAP. YM-58483 also inhibits the release of spinal cord IL-1β, TNF-α, and PGE2<sup>[1]</sup>. YM-58483 and cyclosporine A inhibits T cell proliferation in a one-way mixed lymphocyte reaction (mLR) with IC<sub>50</sub> values of 330 and 12.7 nM, respectively<sup>[2]</sup>. YM-58483 inhibits DNP antigen-induced histamine release from and leukotrienes (LTs) production in IgE-primed RBL-2H3 cells, a rat basophilic leukemia cell line, with IC<sub>50</sub> values of 460 and 310 nM, respectively. YM-58483 also inhibits phytohemagglutinin-P (PHA)-stimulated IL-5 and IL-13 production in human peripheral blood cells with IC<sub>50</sub> values of 125 and 148 nM, respectively, which is approximately 5 times less potent than prednisolone<sup>[3]</sup>. YM-584<br><br>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/ym-58483.html">www.medchemexpress.cn/ym-58483.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

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