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Thiomyristoyl研究进展

发布日期：2017-10-27   浏览次数：0
核心提示：a href=https://www.medchemexpress.com/Thiomyristoyl.htmlThiomyristoyl/a产品描述：Thiomyristoyl is a potent and specific
<a href="https://www.medchemexpress.com/Thiomyristoyl.html">Thiomyristoyl</a>产品描述：
Thiomyristoyl is a potent and specific <b>SIRT2</b> inhibitor with an <b>IC<sub>50</sub></b> of 28 nM.

IC50 & Target: IC50: 28 nM (SIRT2)<sup>[1]</sup>

<i><b>In Vitro:</b></i> Thiomyristoyl (TM) is a potent SIRT2-specific inhibitor with broad anticancer activity but little effect on non-cancerous cells. SIRT2-inhibition promotes c-Myc ubiquitination and degradation, suggesting the therapeutic potential of TM to target certain c-Myc-driven cancers. TM could inhibit SIRT2 with an IC<sub>50</sub> of 28 nM, but inhibits SIRT1 with an IC<sub>50</sub> value of 98 μM and does not inhibit SIRT3 even at 200 μM. TM inhibits three human breast cancer cell lines, MCF-7, MDA-MB-468, and MDA-MB-231<sup>[1]</sup>.

<i><b>In Vivo:</b></i> TM inhibits tumor growth in mouse models of breast cancer. TM does not cause significant toxicity in mice and no significant weight loss is observed in TM-treated mice. S5H, the acetyl-a-tubulin level is moderately but statistically significantly increased in tum<br><br>
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