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L-Homocysteine thiolactone (hy

发布日期：2017-10-30   浏览次数：0
核心提示：a href=https://www.medchemexpress.com/L-Homocysteine_thiolactone_hydrochloride.htmlL-Homocysteine thiolactone (hydrochlo
<a href="https://www.medchemexpress.com/L-Homocysteine_thiolactone_hydrochloride.html">L-Homocysteine thiolactone (hydrochloride)</a>产品描述：L-Homocysteine thiolactone hydrochloride is an intramolecular thioester of homocysteine; prevents translational incorporation of homocysteine into proteins.

<i><b>In Vitro:</b></i> In all cell types, from bacterial to human, homocysteine is metabolized to homocysteine thiolactone by methionyl-tRNA synthetase. Elevated levels of homocysteine are an independent risk factor for cardiovascular disease in humans. Homocysteine can be harmful to human cells because of its metabolic conversion to homocysteine thiolactone, a reactive thioester. This conversion occurs in all human cell types, including endothelial cells<sup>[1]</sup>. Homocysteine thiolactone induces cell death and features of apoptosis including increased phosphotidylserine exposure on the membrane surface, increased apoptotic cells with hypoploid DNA contents, and internucleosomal DNA fragmentation in HL-60 cells<sup>[2]</sup>. Homocysteine thiolactone is cytotoxic and capable of promoting cell death, as measured by caspase-<br><br>
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