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ST-193 (hydrochloride)研究进展

发布日期：2017-10-30   浏览次数：0
核心提示：a href=https://www.medchemexpress.com/ST-193_hydrochloride.htmlST-193 (hydrochloride)/a产品描述：ST-193 hydrochloride is
<a href="https://www.medchemexpress.com/ST-193_hydrochloride.html">ST-193 (hydrochloride)</a>产品描述：ST-193 hydrochloride is a potent broad-spectrum <b>arenavirus</b> inhibitor; inhibits Guanarito, Junin, Lassa and Machupo virus with <b>IC<sub>50</sub></b> values of 0.44, 0.62, 1.4 and 3.1 nM, respectively.

IC50 & Target: IC50: 0.44 nM (Guanarito), 0.62 nM (Junin), 1.4 nM (Lassa) and 3.1 nM (Machupo)<sup>[1]</sup>

<i><b>In Vitro:</b></i> ST-193 inhibits LASV pseudotypes with an IC<sub>50</sub> of 1.6 nM. ST-193 inhibits pseudotypes generated with other arenavirus envelopes as well, including the remaining four commonly associated with hemorrhagic fever (IC<sub>50</sub>s for Junín, Machupo, Guanarito, and Sabiá are in the 0.2 to 12 nM range) but exhibits no antiviral activity against pseudotypes incorporating either the GP from the LASV-related arenavirus lymphocytic choriomeningitis virus or the unrelated G protein from vesicular stomatitis virus, at concentrations of up to 10 μM<sup>[2]</sup>.

<i><b>In Vivo:</b></i> ST-193 is found to be tolerated well when administered daily as<br><br>
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