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Emodepside研究进展

发布日期：2017-10-30   浏览次数：0
核心提示：a href=https://www.medchemexpress.com/Emodepside.htmlEmodepside/a产品描述：Emodepside (PF 1022-221) is a cyclooctadepsip
<a href="https://www.medchemexpress.com/Emodepside.html">Emodepside</a>产品描述：Emodepside (PF 1022-221) is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity.

<i><b>In Vitro:</b></i> Emodepside is a semisynthetic derivative of PF1022A, which contains a morpholine attached in para position at each of both D-phenyllactic acids. Emodepside is efficacious against a variety of gastrointestinal nematodes. Emodepside binds to a presynaptic latrophilin receptor in nematodes<sup>[1]</sup>. Emodepside produces a slow time-dependent (20 min), 4-aminopyridine sensitive, concentration-dependent hyperpolarization and increase in voltage-activated K currents. Emodepside has an inhibitory effect on spiking. Emodepside significantly inhibits the ryanodine increase in spike frequency between the 20 and 35 min period by 9.8 spikes/min<sup>[2]</sup>. In the presence of emodepside, highly increased currents are observed without depolarization up to a threshold of 0 mV and without any additional stimuli to artificially increase [Ca <sup>2+</sup>]i levels. These novel <br><br>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/emodepside.html">www.medchemexpress.cn/emodepside.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

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