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Optovin研究进展

发布日期：2017-11-01   浏览次数：0
核心提示：a href=https://www.medchemexpress.com/Optovin.htmlOptovin/a产品描述：Optovin is a reversible photoactive TRPA1 activator
Optovin产品描述：Optovin is a reversible photoactive TRPA1 activator; stimulates human TRPA1 channels in vitro and enables repeated photoactivation of motor behaviors in wild-type zebrafish (EC50 = 2 μM).IC50 value:Target: in vitro: Optovin is a rhodanine-containing small molecule with no previously annotated biological activity. wheras DMSO-treated animals do not respond to photic stimuli, optovin-treated animals respond to light with vigorous motor excitation at an EC50 of 2 μM. Optovin-treated animals respond to 387 nm (violet) stimuli, but not to 485 nm (blue), 560 nm (green) or longer wavelengths. optovin strongly activated 33% (35/105) of DRG neurons. optovin acts on a molecular target expressed in mustard oil responsive mammalian DRG sensory neurons; perhaps on TRPA1 itself. TrpA1 is necessary for the optovin response [1].in vivo: Optovin also elicited nociceptive behaviors in adult mice.  optovin shows activity on adult animals in vivo, and may be preferable to conventional TRPA1 liga


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产品链接：www.medchemexpress.cn/optovin.html