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ATN-161 (trifluoroacetate sal

发布日期：2017-11-06   浏览次数：0
核心提示：a href=https://www.medchemexpress.com/ATN-161-trifluoroacetate-salt.htmlATN-161 (trifluoroacetate salt)/a产品描述：ATN-1
ATN-161 (trifluoroacetate salt)产品描述：ATN-161 trifluoroacetate salt is a novel integrin α5β1 antagonist, which inhibits angiogenesis and growth of liver metastases in a murine model.IC50 & Target: Integrin α5β1[1]In Vitro: The combination of ATN-161 plus 5-FU significantly reduces tumor cell proliferation compared to control and single-agent therapy (p<0.01). In addition, combination therapy leads to a significant increase of apoptotic (TUNEL-positive) tumor cells (p<0.03), wheras single-agent therapy does not increase in TUNEL-positive tumor cells. ATN-161 treatment leads to a significant reduction in EC number (21% decrease) after a 48 hr incubation time compared to control (p<0.03)[1]. ATN-161 inhibites VEGF-induced migration and capillary tube formation in hCECs, but did not inhibit proliferation. ATN-161 decreases the number of cells migrating in response to VEGF in a dose-dependent manner starting at 100 nM (P<0.001 vs. VEGF group)[2]. In Vivo:<


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