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IRAK inhibitor 4说明

发布日期:2018-04-18   来源:MedChemExpress   作者:MedChemExpress   浏览次数:0
核心提示:IRAK inhibitor 4 是白细胞介素-1 受体相关激酶-4 (IRAK4) 的抑制剂。
IRAK inhibitor 4 是白细胞介素-1 受体相关激酶-4 (IRAK4) 的抑制剂。
Abarelix产品描述:Abarelix is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer treatment.
In Vitro: Abarelix (30 and 300 μg/mL) and cetrorelix cause significantly increased histamine release[1]. Abarelix is the first GnRH antagonist to be developed, and can produce rapid and sustained decreases in testosterone to castrate levels without the need for co-administration of an antiandrogen, and with a very low complication rate in the short term[2]. Abarelix demonstrates to promptly and substantially reduce follicle-stimulating hormone levels to lower than LHRH agonist. Abarelix does not cause a surge in serum testosterone that can precipitate a flare phenomenon or worsening of disease, particularly dangerous for patients with metastatic, symptomatic disease, and produces medical castration more quickly[3].


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产品链接:www.medchemexpress.cn/Abarelix.html

Purity:98%
MWt:620.6646
Formula:C33H35F3N6O3
SMILES:OC1CCC(N2C3=C(C=C(C=C3)C(NCCC(C)C)=O)N=C2NC4=NNC5=C4C=C(C=C5)C6=CC=CC=C6OC(F)(F)F)CC1
Pathway:Immunology/Inflammation; Protein Tyrosine Kinase/RTK;
Mechanisms:IRAK;
Research Area:Inflammation/Immunology
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