BVT 2733产品描述：BVT 2733 is a new, small molecule, non-steroidal, isoform-selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1). IC50 value: Target: 11β-HSD1 inhibitor in vitro: in vivo: BVT 2733 lowered hepatic PEPCK and glucose-6-phosphatase mRNA, blood glucose and serum insulin concentrations compared with vehicle treated mice [1]. CIA mice were treated with BVT-2733 (100 mg/kg, orally) or vehicle twice daily for 2 weeks. BVT-2733 treatment attenuated the arthritis severity and anti-CII level in CIA mice. BVT-2733 also decreased the levels of serum TNF-α, IL-1β, IL-6 and IL-17. BVT-2733 treatment also significantly reduced synovial inflammation and joint destruction [2]. Mice receiving BVT 2733 treatment exhibited decreased body weight and enhanced glucose tolerance and insulin sensitivity compared to control mice. BVT 2733 also down-regulated the expression of inflammation-related genes including monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor alpha
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产品链接：www.medchemexpress.cn/BVT-2733.html
Purity:98%
MWt:314.3027
Formula:C13H14N8O2
SMILES:O=C1C(N2N=NC=C2)=CNN1C3=NC=NC(N4CCOCC4)=C3
Pathway:metabolic Enzyme/Protease;
Mechanisms:HIF/HIF Prolyl-Hydroxylase;
Research Area:Cardiovascular Disease
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