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NT157

发布日期：2017-10-26   浏览次数：0
核心提示：a href=https://www.medchemexpress.com/NT157.htmlNT157/a产品描述：NT157is a selective inhibitor of IRS-1/2, IC50 values a
<a href="https://www.medchemexpress.com/NT157.html">NT157</a>产品描述：NT157is a selective inhibitor of IRS-1/2,  IC50 values at sub-micromolar doses (ranging from 0.3 to 0.8 μM) .

IC50 value: 0.3 to 0.8 μM [1]

Target: Insulin receptor

in vitro: NT157 significantly affects the cells' migratory ability, as confirmed by a wound-healing assay. NT157 induces cytostatic effects, as evidenced by G2/M cell cycle arrest, and does not affect apoptosis. NT157, a novel small-molecule that specifically targets IRS protein, in OS cells. NT157 is a small-molecule inhibitor that induces Ser-phosphorylation and consequently the degradation of IRS-1 and IRS-2. NT157 efficiently affects migration ability of MG-63 and U-2OS OS cells. NT157 treatment induces cell cycle arrest and inhibits IGF system signaling. [1] The density of LNCaP cells grown in FBS was decreased approximately 20% at 1 μM, approximately 70% at 2 μM, and >90% at 5 μM (IC50, 1.4 μM). Growth of LNCaP cells is suppressed >60% when cultured in CSS but still exhibited significant density at 2 μM and maxima<br><br>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/nt157.html">www.medchemexpress.cn/nt157.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

alt="">
 
 
 
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