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SZL P1-41

发布日期：2017-10-26   浏览次数：0
核心提示：a href=https://www.medchemexpress.com/SZL-P1-41.htmlSZL P1-41/a产品描述：SZL P1-41 is Skp2 inhibitor, selectively suppre
<a href="https://www.medchemexpress.com/SZL-P1-41.html">SZL P1-41</a>产品描述：SZL P1-41 is Skp2 inhibitor, selectively suppresses Skp2 E3 ligase activity,  but not activity of other SCF complexes.

target:  Skp2

In vitro: SZL P1-41 also phenocopies the effects observed upon genetic Skp2 deficiency, such as suppressing survival, Akt-mediated glycolysis as well as triggering p53-independent cellular senescence. SZL P1-41  prevent Skp2-Skp1 interactions and Skp2 SCF E3 ligase activity. The reference concentration is 5 uM. SZL P1-41 restricts cancer cell survival through triggering p53-independent cellular senescence and inhibiting aerobic glycolysis.

In vivo: SZL P1-41 exhibits potent anti-tumor activities in multiple animal models and cooperates with chemotherapeutic agents to reduce cancer cell survival.

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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/szl-p1-41.html">www.medchemexpress.cn/szl-p1-41.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

alt="">
 
 
 
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