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Y-33075

发布日期：2017-10-26   浏览次数：0
核心提示：a href=https://www.medchemexpress.com/Y-33075.htmlY-33075/a产品描述：Y-33075 is potent and selective p160ROCK inhibitor
<a href="https://www.medchemexpress.com/Y-33075.html">Y-33075</a>产品描述：Y-33075 is potent and selective p160ROCK inhibitor with an Ki value of 0.14 uM, > 200 fold selectivity for p160ROCK than PKC, cAMP-dependent protein kianse and Mypsin light-chain kinase.

IC50 value: 0.14 uM (Ki) [1]

Target: p160ROCK

Y-27632 is a representative compound which potently inhibits phenylephrine-induced contraction of rabbit aortic strips, with a half-maximal inhibitory concentration (IC50) of 0.7 uM ; however, it had little effect on contraction induced by potassium chloride (IC50 > 30 uM). Y-27632 also inhibited the contraction of pig coronary artery strips and guinea-pig trachea induced by various agonists such as phenylephrine, histamine, acetylcholine, serotonin, endothelin and a thromboxane agonist, U-46619 (IC50 values of 0.3–1 uM). These results indicate that Y-27632 is a specific and potent inhibitor of agonist-induced smooth-muscle contraction [1].<br><br>
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<span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">公司介绍：MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库，总部位于美国新泽西，分别在瑞典和上海设有欧洲区子公司和亚洲区总代理，营销网点遍及全球20多个国家地区。MCE经过多年努力已成为全球生物活性小分子领域的一流供应商， 产品涵盖癌症、神经科学、抗感染、表观遗传学等20个热门研究领域，PI3K、MAPK等近千个细分靶点，超过4000个活性小分子化合物现货，以及GPCR、API、离子通道等超过20种不同类型的化合物库，同时提供从毫克到千克的专业定制合成服务。</span>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/y-33075.html">www.medchemexpress.cn/y-33075.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

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