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Piperoxan (hydrochloride)研究进展

发布日期：2017-10-27   浏览次数：0
核心提示：a href=https://www.medchemexpress.com/Piperoxan-hydrochloride.htmlPiperoxan (hydrochloride)/a产品描述：Piperoxan hydroch
<a href="https://www.medchemexpress.com/Piperoxan-hydrochloride.html">Piperoxan (hydrochloride)</a>产品描述：Piperoxan hydrochloride is an α<sub>2</sub> adrenoceptor antagonist.

IC50 & Target: adrenoceptor<sup>[1]</sup>

<i><b>In Vitro:</b></i> When the medulla is superfused with α<sub>2</sub> adrenoceptor antagonist Piperoxane (50 μM; 5 min) while the pons is with artificial cerebrospinal fluid (ACSF), the three inactive preparations display rhythmic phrenic bursts at a low frequency (2-4 c/min), and the phrenic burst frequency of the 12 active ones significantly increases during the last 3 min of Piperoxane applications (163±12% of the previous mean frequency). In active medullary preparations, the effects of NA applications (25 μM; 5 min) are compared when the preparations sre superfused either by ACSF (n=8) or by the α2 adrenoceptor antagonist Piperoxane (50 μM; PIP-ACSF; n=5). NA applications either alone (NA-ACSF) or with Piperoxane (PIP-ACSF+NA) significantly increases the phrenic burst frequency. However, the blockage of the medullary α2 adrenoceptors by Piperoxane potentiates a phr<br><br>
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