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TPPU研究进展

发布日期：2017-10-27   浏览次数：0
核心提示：a href=https://www.medchemexpress.com/TPPU.htmlTPPU/a产品描述：TTPU is a soluble epoxide hydrolase (bsEH/b) inhibitor wi
<a href="https://www.medchemexpress.com/TPPU.html">TPPU</a>产品描述：TTPU is a soluble epoxide hydrolase (<b>sEH</b>) inhibitor with <b>IC<sub>50</sub></b> values of 37 and 3.7 nM for monkey and human sEH, respectively.

IC50 & Target: IC50: 37 nM (Monkey sEH), 3.7 nM (Human sEH)<sup>[1]</sup>

<i><b>In Vitro:</b></i> Soluble epoxide hydrolase inhibitors (sEHIs) possess anti-inflammatory, antiatherosclerotic, antihypertensive and analgesic properties<sup>[1]</sup>. In the Caco-2 cells permeability assay, TPPU rapidly passes the cell monolayer, suggesting it will have a good intestinal permeability<sup>[2]</sup>.

<i><b>In Vivo:</b></i> TPPU is suitable for investigating soluble epoxide hydrolase biology and the role of epoxide-containing lipids in modulating inflammatory diseases. TPPU displays high plasma concentrations when dosed orally at 0.3 mg/kg and drug-like properties. The C<sub>max</sub> increases with dose from 0.3 to 3 mg/kg for TPPU<sup>[1]</sup>.  Following administration in drinking water to rats (0.2, 1, and 5 mg TPPU/L with 0.2% PEG400)<br><br>
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