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MBP146-78研究进展

发布日期：2017-10-30   浏览次数：0
核心提示：a href=https://www.medchemexpress.com/MBP146-78.htmlMBP146-78/a产品描述：MBP146-78 is a potent and selective inhibitor o
<a href="https://www.medchemexpress.com/MBP146-78.html">MBP146-78</a>产品描述：MBP146-78 is a potent and selective inhibitor of <b>cGMP</b> dependent protein kinases.

<i><b>In Vitro:</b></i> MBP146-78 displays a dose-dependent inhibition of <i>T. gondii</i> tachyzoites replicating inside HFFs, with an <b>IC<sub>50</sub></b> of 210 nM. The suppression of lytic parasite growth by MBP146-78 is reversible. Replacement of the medium with medium lacking MBP146-78, after treatment for up to 7 days at 2 μM, results in complete lysis of HFF cell monolayers. MBP146-78 is neither toxic nor inhibitory to proliferating or confluent monolayers of HFFs at concentrations of up to 10 μM<sup>[1]</sup>.

<i><b>In Vivo:</b></i> In infected mice that are treated with MBP146-78 at 50 mg/kg twice daily, parasites are undetectable throughout the 10-day treatment period in each of the tissues examined. However, samples from brain, spleen, and lung taken from infected treated mice reveal the presence of parasites after cessation of administration of MBP146-78, indicating that a transien<br><br>
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