Remodelin产品描述：Remodelin is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10. IC50 value: Target: NAT10 inhibitor Remodelin can improve nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and HGPS-derived patient cells, and decrease markers of DNA damage in these cells. Using a combination of chemical, cellular, and genetic approaches, acetyl-transferase protein NAT10 was identified as the target of Remodelin that mediated nuclear shape rescue in laminopathic cells via microtubule reorganization. Down-regulation and mutations of the nuclear-architecture proteins lamin A and C cause misshapen nuclei and altered chromatin organization associated with cancer and laminopathies, including the premature-aging disease Hutchinson-Gilford progeria syndrome (HGPS). Remodelin is a useful chemical tool to study how NAT10 affects nuclear architecture and suggest alternative strategies for treating laminopathies and aging.
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产品链接：www.medchemexpress.cn/Remodelin.html
Purity:98%
MWt:505.0079
Formula:C28H29ClN4O3
SMILES:O=C1NC(C(C2=CN(C3=CC=CC=C32)CCO[C@H](CN(C)C)CC4)=C1C5=CN4C6=CC=CC=C56)=O.[H]Cl
Pathway:Epigenetics; TGF-beta/Smad;
Mechanisms:PKC;
Research Area:Cancer
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