RI-1说明

RI-1是RAD51抑制剂，IC50在5到30 μM之间。
IOX2产品描述：IOX2 is a specific prolyl hydroxylase-2 (PHD2) inhibitor with IC₅₀ of 22 nM. IC50 & Target: IC50: 22 nM (PHD2)^[1] In Vitro: IOX2 is at least 2-5000 fold selective, as judged by IC₅₀ values, for PHD2 over the KDMs and Factor Inhibiting HIF(FIH)^[1]. IOX2 significantly upregulates the transcription of VEGF-A and BNIP3 in normal human epidermal keratinocytes (NHEK) and normal human dermal fibroblasts (NHDF) when grown under normoxia and hypoxia. IOX2 efficiently promotes HIF-1α stability, nuclear translocation, and target gene expression in keratinocytes and fibroblasts. In addition, IOX2 significantly upregulates biosynthesis and transcription of VEGF-A and BNIP3 in sulfur mustard (SM)-exposed NHEK and NHDF grown under hypoxia. These results suggest that application of IOX2 is useful for restoring of SM-affected HIF-1α stability and signaling activity in keratinocytes and fibroblasts^[2]. In


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MCE 定期增加各领域热门抑制剂、激动剂，不断扩增已有化合物库，以满足最新的科研需求；
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产品链接：www.medchemexpress.cn/IOX2.html


Purity:98%
MWt:361.6077
Formula:C14H11Cl3N2O3
SMILES:O=C(C(N1CCOCC1)=C2Cl)N(C3=CC=C(Cl)C(Cl)=C3)C2=O
Pathway:Cell Cycle/DNA Damage;
Mechanisms:RAD51;
Research Area:Cancer
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