65836-72-8：产品说明书

65836-72-8：产品说明书

                                                <a href="https://www.medchemexpress.com/DKM_2-93.html">DKM 2-93</a>产品描述：DKM 2-93 is a relatively selective inhibitor of <b>UBA5</b> with an <b>IC₅₀</b> of 430 μM.IC50 &amp; Target: IC50: 430 μM (UBA5), 90 μM (PaCa2 cells), 30 μM (Panc1 cells)^[1]<i><b>In Vitro:</b></i> Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC₅₀s of 90 and 30 μM, respectively^[1].<i><b>In Vivo:</b></i> DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells <i>in vivo</i> in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity^[1].<br /><br /><br /><span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">公司介绍：MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库，总部位于美国新泽西，分别在瑞典和上海设有欧洲区子公司和亚洲区总代理，营销网点遍及全球20多个国家地区。MCE经过多年努力已成为全球生物活性小分子领域的一流供应商， 产品涵盖癌症、神经科学、抗感染、表观遗传学等20个热门研究领域，PI3K、MAPK等近千个细分靶点，超过4000个活性小分子化合物现货，以及GPCR、API、离子通道等超过20种不同类型的化合物库，同时提供从毫克到千克的专业定制合成服务。</span><br style="color: rgb(62,62,62);" /><span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">MCE 对每批产品都进行严格的LCMS和NMR检验，其产品已被全球近万名客户广泛使用并发表大量文章、专利；</span><br style="color: rgb(62,62,62);" /><span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">MCE 定期增加各领域热门抑制剂、激动剂，不断扩增已有化合物库，以满足最新的科研需求；</span><br style="color: rgb(62,62,62);" /><span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">数千种产品在上海有充足备货，24-48小时内送达客户；</span><br style="color: rgb(62,62,62);" /><span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">大量产品提供免费试用装；</span><span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);">已为全球多个知名企业、院校构建各种定制型化合物库。</span><br /><br />产品链接：<a href="http://www.medchemexpress.cn/dkm-2-93.html">www.medchemexpress.cn/dkm-2-93.html</a><br /><br /><img alt=""  src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg" style="width: 600.0px;height: 310.0px;" />                                            </div>