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Z-IETD-FMK研究进展

发布日期：2017-10-27   浏览次数：0
核心提示：a href=https://www.medchemexpress.com/Z-IETD-FMK.htmlZ-IETD-FMK/a产品描述：Z-IETD-FMK is a selective and cell permeable
<a href="https://www.medchemexpress.com/Z-IETD-FMK.html">Z-IETD-FMK</a>产品描述：Z-IETD-FMK is a selective and cell permeable <b>caspase 8</b> inhibitor.

<i><b>In Vitro:</b></i> Z-IETD-FMK causes full inhibition only of the proapoptotic effect of TNFα with an IC<sub>50</sub> of 0.46 μM<sup>[1]</sup>. Z-IETD-FMK and Z-VAD-FMK at non-toxic doses are found to be immunosuppressive and inhibit human T cell proliferation induced by mitogens and IL-2. They are shown to block NF-κB in activated primary T cells, but have little inhibitory effect on the secretion of IL-2 and IFN-γ during T cell activation<sup>[2]</sup>. Z-IETD-FMK inhibits the cleavage of caspase-8 and only partially inhibits the cleavage of caspase-3 and PARP. Z-IETD-FMK can prevent the execution of apoptosis in retinal cells exposed to different apoptotic stimuli<sup>[3]</sup>.

<i><b>In Vivo:</b></i> Pharmacological inhibition of caspase-8 by z-IETD-FMK robustly reduces tumour outgrowth and this is closely associated with a reduction in the release of pro-inflammatory cytokines, IL-6, TNF-α, IL-18, IL-1<br><br>
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