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N2-Methylguanine研究进展

发布日期：2017-10-30   浏览次数：0
核心提示：a href=https://www.medchemexpress.com/N2-Methylguanine.htmlN2-Methylguanine/a产品描述：N2-Methylguanine is a modified nu
<a href="https://www.medchemexpress.com/N2-Methylguanine.html">N2-Methylguanine</a>产品描述：N2-Methylguanine is a modified nucleoside. N2-Methylguanine is an endogenous methylated nucleoside found in human fluids.

<i><b>In Vitro:</b></i> N2-methylguanine is found within both helical and looped regions of RNA secondary structure, and it can exist in either the s-cis or the s-trans rotamer. If there is a rotational preference for the methyl group, the effect of N2-methylguanine substitution may be specific to the sequence context depending upon which face of the base participates in hydrogen bonding<sup>[1]</sup>. N2-methylguanine is the principal kinetic barrier for reverse transcription in the 1340 bases proximal to the 5' end of <i>E. coli</i> 16S rRNA. Transcription intermediates correspond to attenuation at the positions of N2-methylguanine in the rRNA sequence. The relaxation time for elongation of the cDNA through m2G is approximately 3 min<sup>[2]</sup>.

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