SR3335产品描述：SR3335 is a selective RORα synthetic ligand, directly binds to RORα (Ki 220 nM) but not other RORs, and functions as a selective partial inverse agonist of RORα in cell-based assays. IC50 & Target: Ki: 220 nM (RORα)[1]
In Vitro: SR3335 is a selective RORα partial inverse agonist. In a biochemical radioligand binding assay using [3H]25-hydroxycholesterol as a label it is clear that unlabeled SR3335 dose-dependently competes for binding to the RORα LBD. The Ki is calculated as 220 nM using the Cheng-Prusoff equation. In a cell-based chimeric receptor Gal4 DNA-binding domain-NR ligand binding domain cotransfection assay, SR3335 significantly inhibits the constitutive transactivation activity of RORα (IC50=480 nM)(partial inverse agonist activity), but has no effect on the activity of LXRα and RORγ[1].
In Vivo: Pharmacokinetic studies indicate that SR3335 displays reasonable exp
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产品链接：www.medchemexpress.cn/SR3335.html
Purity:98%
MWt:413.4883
Formula:C25H19NO3S
SMILES:O=C1C=C(N2CCOCC2)OC3=C1C=CC=C3C4=CC=CC5=C4SC6=C5C=CC=C6
Pathway:Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR;
Mechanisms:CRISPR/Cas9; DNA-PK; Epigenetic Reader Domain;
Research Area:Cancer
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