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Salvianolic acid B说明

发布日期:2018-04-20   浏览次数:0
核心提示:Salvianolic acid B 是丹参的重要组分,它常用来治疗微循环疾病。
Salvianolic acid B 是丹参的重要组分,它常用来治疗微循环疾病。
BAY 57-1293产品描述:BAY 57-1293 represents a new class of potent inhibitors of herpes simplex virus (HSV) that target the virus helicase primase complex. IC50 Value: 20 nM (HSV-1) [1] Target: HSV in vitro: BAY 57-1293 is nearly two orders of magnitude more potent than acyclovirin vitro and the superiority was even more prominent when the viral load was increased (BAY 57-1293 IC50 = 12 nM, 20 nM and 50 nM; acyclovir IC50 = 1uM, 3M and 10 50 uM at a multiplicity of infection (m.o.i.) of 0.0025, 0.02 and 0.2, respectively). A minor increase in IC50 values at higher viral loads was observed for all thiazolyl compounds listed in Table 1. BAY 57-1293 was also active against porcine (IC50 = 5 uM) and bovine (IC50 = 0.12 uM) herpes strains [1]. in vivo: Delayed treatment with BAY 57-1293 (20 mg/kg 2× daily per os, treatment day 4-14) abrogates progression of disease symptoms (mean of 10 animals per group) of HSV-2 infected guinea pigs within 1 d of treatment and healing is observed subsequently, wheras a 7.


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MCE 对每批产品都进行严格的LCMS和NMR检验,其产品已被全球近万名客户广泛使用并发表大量文章、专利;
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产品链接:www.medchemexpress.cn/BAY-57-1293.html


Purity:98%
MWt:718.6138
Formula:C36H30O16
SMILES:O=C([C@@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=C(O)C=CC(/C=C/C(O[C@@H](C(O)=O)CC4=CC=C(O)C(O)=C4)=O)=C13)O[C@@H](C(O)=O)CC5=CC=C(O)C(O)=C5
Pathway:Autophagy;
Mechanisms:Autophagy;
Research Area:Cardiovascular Disease
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关键词: Salvianolic acid B